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Title:

Murine cardiac growth, TRPC channels, and cGMP kinase I.

Document type:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Author(s):
Domes, Katrin; Patrucco, Enrico; Loga, Florian; Dietrich, Alexander; Birnbaumer, Lutz; Wegener, Jörg W; Hofmann, Franz
Abstract:
Signaling via cGMP-dependent protein kinase I (cGKI) and canonical transient receptor potential (TRPC) channels appears to be involved in the regulation of cardiac hypertrophy. Recent evidence suggests that TRPC channels are targets for cGKI, and phosphorylation of these channels may mediate the antihypertrophic effects of cGMP signaling. We tested this concept by investigating the role of cGMP/cGKI signaling on angiotensin II (A II)-induced cardiac hypertrophy using a control group (Ctr), trpc6...     »
Journal title abbreviation:
Pflugers Arch
Year:
2015
Journal volume:
467
Journal issue:
10
Pages contribution:
2229-34
Language:
eng
Fulltext / DOI:
doi:10.1007/s00424-014-1682-0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25547873
Print-ISSN:
0031-6768
TUM Institution:
Institut für Pharmakologie und Toxikologie
 BibTeX