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Title:

B lymphocytes in neuromyelitis optica.

Document type:
Journal Article; Review
Author(s):
Bennett, JeffreyL; OConnor, KevinC; Bar-Or, Amit; Zamvil, ScottS; Hemmer, Bernhard; Tedder, ThomasF; von Budingen, H-Christia; Stuve, Olaf; Yeaman, MichaelR; Smith, TerryJ; Stadelmann, Christine
Abstract:
Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4). These autoantibodies are predominantly IgG1, and considerable evidence supports their pathogenicity, presumably by binding to AQP4 on CNS astrocytes, resulting in astrocyte injury and inflammation. Convergent clinical...     »
Journal title abbreviation:
Neurol Neuroimmunol Neuroinflamm
Year:
2015
Journal volume:
2
Journal issue:
3
Pages contribution:
-
Language:
eng
TUM Institution:
Neurologische Klinik und Poliklinik
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