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Title:

Host microbiota constantly control maturation and function of microglia in the CNS.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Erny, Daniel; Hrab? de Angelis, Anna Lena; Jaitin, Diego; Wieghofer, Peter; Staszewski, Ori; David, Eyal; Keren-Shaul, Hadas; Mahlakoiv, Tanel; Jakobshagen, Kristin; Buch, Thorsten; Schwierzeck, Vera; Utermöhlen, Olaf; Chun, Eunyoung; Garrett, Wendy S; McCoy, Kathy D; Diefenbach, Andreas; Staeheli, Peter; Stecher, Bärbel; Amit, Ido; Prinz, Marco
Abstract:
As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. We observed substantial contributions of the host microbiota to microglia homeostasis, as germ-free (GF) mice displayed global defects in microglia with altered cell proportions and an immature phenotype, leading to impaired innate immune responses. Temporal eradication of host microbiota severely c...     »
Journal title abbreviation:
Nat Neurosci
Year:
2015
Journal volume:
18
Journal issue:
7
Pages contribution:
965-77
Language:
eng
Fulltext / DOI:
doi:10.1038/nn.4030
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26030851
Print-ISSN:
1097-6256
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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