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Titel:

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

Dokumenttyp:
Journal Article
Autor(en):
Textor, Ana; Schmidt, Karin; Kloetzel, Peter-M; Weißbrich, Bianca; Perez, Cynthia; Charo, Jehad; Anders, Kathleen; Sidney, John; Sette, Alessandro; Schumacher, Ton N M; Keller, Christin; Busch, Dirk H; Seifert, Ulrike; Blankenstein, Thomas
Abstract:
Adoptive T cell therapy (ATT) can achieve regression of large tumors in mice and humans; however, tumors frequently recur. High target peptide-major histocompatibility complex-I (pMHC) affinity and T cell receptor (TCR)-pMHC affinity are thought to be critical to preventing relapse. Here, we show that targeting two epitopes of the same antigen in the same cancer cells via monospecific T cells, which have similar pMHC and pMHC-TCR affinity, results in eradication of large, established tumors whe...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2016
Band / Volume:
213
Heft / Issue:
11
Seitenangaben Beitrag:
2333-2348
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20160636
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27697836
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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