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Title:

Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice.

Document type:
Journal Article; Article
Author(s):
Backes, Simone; Jäger, Clemens; Dembek, Claudia J; Kosinska, Anna D; Bauer, Tanja; Stephan, Ann-Sophie; Di?lers, Andris; Mutwiri, George; Busch, Dirk H; Babiuk, Lorne A; Gasteiger, Georg; Protzer, Ulrike
Abstract:
Therapeutic vaccination is a novel treatment approach for chronic hepatitis B, but only had limited success so far. We hypothesized that optimized vaccination schemes have increased immunogenicity, and aimed at increasing therapeutic hepatitis B vaccine efficacy.Modified Vaccinia virus Ankara (MVA) expressing hepatitis B virus (HBV) antigens was used to boost protein-prime vaccinations in wildtype and HBV-transgenic (HBVtg) mice.Protein-prime/MVA-boost vaccination was able to overcome HBV-specif...     »
Journal title abbreviation:
Vaccine
Year:
2016
Journal volume:
34
Journal issue:
7
Pages contribution:
923-32
Language:
eng
Fulltext / DOI:
doi:10.1016/j.vaccine.2015.12.060
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26776470
Print-ISSN:
0264-410X
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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