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Title:

Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing.

Document type:
Journal Article
Author(s):
Tagawa, Takanobu; Albanese, Manuel; Bouvet, Mickaël; Moosmann, Andreas; Mautner, Josef; Heissmeyer, Vigo; Zielinski, Christina; Lutter, Dominik; Hoser, Jonathan; Hastreiter, Maximilian; Hayes, Mitch; Sugden, Bill; Hammerschmidt, Wolfgang
Abstract:
Epstein-Barr virus (EBV) is a tumor virus that establishes lifelong infection in most of humanity, despite eliciting strong and stable virus-specific immune responses. EBV encodes at least 44 miRNAs, most of them with unknown function. Here, we show that multiple EBV miRNAs modulate immune recognition of recently infected primary B cells, EBV's natural target cells. EBV miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of na...     »
Journal title abbreviation:
J Exp Med
Year:
2016
Journal volume:
213
Journal issue:
10
Pages contribution:
2065-80
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20160248
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27621419
Print-ISSN:
0022-1007
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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