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Title:
Next-generation TCR sequencing - a tool to understand T-cell infiltration in human cancers.
Document type:
Journal Article
Author(s):
Poschke, Isabel; Flossdorf, Michael; Offringa, Rienk
Abstract:
Tumour-infiltrating lymphocytes (TILs) are known to mediate potent anti-tumour activity. As T-cell-based therapies start to reach clinical practice, it becomes increasingly important to understand what characterizes a successful anti-tumour T-cell response and to exploit this knowledge for patient stratification. Next-generation sequencing of T-cell receptors (TCRs) promises to provide insights into the complexity of the tumour T-cell infiltrate that go beyond the phenotypic level. A recent study by Chen et al made use of this novel technology to demonstrate that the TIL repertoire of oesophageal squamous cell carcinoma patients is distinct from that of non-tumour sites and is characterized by significant intratumoural heterogeneity. This study illustrates the great potential of the method and addresses several technical and biological hurdles that need to be considered. Careful sampling, normalization, and error correction will be required to optimally use TCR sequencing to answer biological questions and define predictive biomarkers, e.g. for cancer immunotherapy. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Journal title abbreviation:
J Pathol
Year:
2016
Journal volume:
240
Journal issue:
4
Pages contribution:
384-386
Language:
eng
Fulltext / DOI:
doi:10.1002/path.4800
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27569598
Print-ISSN:
0022-3417
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
BibTeX
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mediaTUM Gesamtbestand
Hochschulbibliographie
2016
Fakultäten
Medizin
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
mediaTUM Gesamtbestand
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TUM School of Medicine and Health
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Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)
2016