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Titel:

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Poschke, Isabel; Faryna, Marta; Bergmann, Frank; Flossdorf, Michael; Lauenstein, Claudia; Hermes, Jennifer; Hinz, Ulf; Hank, Thomas; Ehrenberg, Roland; Volkmar, Michael; Loewer, Martin; Glimm, Hanno; Hackert, Thilo; Sprick, Martin R; Höfer, Thomas; Trumpp, Andreas; Halama, Niels; Hassel, Jessica C; Strobel, Oliver; Buchler, Markus; Sahin, Ugur; Offringa, Rienk
Abstract:
The devastating prognosis of patients with resectable pancreatic ductal adenocarcinoma (PDA) presents an urgent need for the development of therapeutic strategies targeting disseminated tumor cells. Until now, T-cell therapy has been scarcely pursued in PDA, due to the prevailing view that it represents a poorly immunogenic tumor.We systematically analyzed T-cell infiltrates in tumor biopsies from 127 patients with resectable PDA by means of immunohistochemistry, flow cytometry, T-cell receptor...     »
Zeitschriftentitel:
Oncoimmunology
Jahr:
2016
Band / Volume:
5
Heft / Issue:
12
Seitenangaben Beitrag:
e1240859
Sprache:
eng
Volltext / DOI:
doi:10.1080/2162402X.2016.1240859
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28123878
Print-ISSN:
2162-4011
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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