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Document type:
Case Reports; Journal Article; Article 
Author(s):
Tancredi, R; Zambelli, A; DaPrada, G A; Fregoni, V; Pavesi, L; Riccardi, A; Burdach, S; Grohar, P J; D'Incalci, M 
Title:
Targeting the EWS-FLI1 transcription factor in Ewing sarcoma. 
Abstract:
Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. This combination was evaluated in Ewing sarcoma patient who was progressing with standard therapies.Trabectedin was given as a 24-h iv infusion on day 1 at the dose of 1 mg/sqm, and irinotecan 75 mg/sqm on day 2 and then on days 2 and 4, every 3 weeks from the...    »
 
Journal title abbreviation:
Cancer Chemother Pharmacol 
Year:
2015 
Journal volume:
75 
Journal issue:
Pages contribution:
1317-20 
Language:
eng 
Print-ISSN:
0344-5704 
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin