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Titel:

Survival control of malignant lymphocytes by anti-apoptotic MCL-1.

Dokumenttyp:
Journal Article; Review; Review
Autor(en):
Fernández-Marrero, Y; Spinner, S; Kaufmann, T; Jost, P J
Abstract:
Programmed apoptotic cell death is critical to maintain tissue homeostasis and cellular integrity in the lymphatic system. Accordingly, the evasion of apoptosis is a critical milestone for the transformation of lymphocytes on their way to becoming overt lymphomas. The anti-apoptotic BCL-2 family proteins are pivotal regulators of the mitochondrial apoptotic pathway and genetic aberrations in these genes are associated with lymphomagenesis and chemotherapeutic resistance. Pharmacological targetin...     »
Zeitschriftentitel:
Leukemia
Jahr:
2016
Band / Volume:
30
Heft / Issue:
11
Seitenangaben Beitrag:
2152-2159
Sprache:
eng
Volltext / DOI:
doi:10.1038/leu.2016.213
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27479182
Print-ISSN:
0887-6924
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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