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Title:

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

Document type:
Journal Article
Author(s):
Michler, Thomas; Große, Stefanie; Mockenhaupt, Stefan; Röder, Natalie; Stückler, Ferdinand; Knapp, Bettina; Ko, Chunkyu; Heikenwälder, Mathias; Protzer, Ulrike; Grimm, Dirk
Abstract:
Hepatitis B virus (HBV) is a promising target for therapies based on RNA interference (RNAi) since it replicates via RNA transcripts that are vulnerable to RNAi silencing. Clinical translation of RNAi technology, however, requires improvements in potency, specificity and safety. To this end, we systematically compared different strategies to express anti-HBV short hairpin RNA (shRNA) in a pre-clinical immunocompetent hepatitis B mouse model. Using recombinant Adeno-associated virus (AAV) 8 vecto...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2016
Journal volume:
8
Journal issue:
9
Pages contribution:
1082-98
Language:
eng
Fulltext / DOI:
doi:10.15252/emmm.201506172
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27473329
Print-ISSN:
1757-4676
TUM Institution:
Institut für Virologie
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