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Title:

Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response.

Document type:
Journal Article; Article
Author(s):
Mayorga, Orlando; Bühler, Silja; Jaeger, Veronika K; Bally, Seraina; Hatz, Christoph; Frösner, Gert; Protzer, Ulrike; van Damme, Pierre; Egger, Matthias; Herzog, Christian
Abstract:
Universal 2-dose hepatitis A virus (HAV) vaccination of toddlers effectively controls hepatitis A. High vaccine costs, however, impede implementation in endemic countries. To test single-dose vaccination as a possible alternative, we initiated an observational, longitudinal study in Nicaragua, to assess protective effectiveness and-through challenge vaccination-humoral immune memory response. After a 2003 serosurvey, 130 originally seronegative children received one dose of virosomal HAV vaccin...     »
Journal title abbreviation:
J Infect Dis
Year:
2016
Journal volume:
214
Journal issue:
10
Pages contribution:
1498-1506
Language:
eng
Fulltext / DOI:
doi:10.1093/infdis/jiw411
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27601623
Print-ISSN:
0022-1899
TUM Institution:
Institut für Virologie
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