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Titel:

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Ma, Chi; Kesarwala, Aparna H; Eggert, Tobias; Medina-Echeverz, José; Kleiner, David E; Jin, Ping; Stroncek, David F; Terabe, Masaki; Kapoor, Veena; ElGindi, Mei; Han, Miaojun; Thornton, Angela M; Zhang, Haibo; Egger, Michèle; Luo, Ji; Felsher, Dean W; McVicar, Daniel W; Weber, Achim; Heikenwälder, Mathias; Greten, Tim F
Abstract:
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer. However, the role of adaptive immune responses in NAFLD-promoted HCC is largely unknown. Here we show, in mouse models and human samples, that dysregulation of lipid metabolism in NAFLD causes a selective loss of intrahepatic CD4(+) but not CD8(+) T lymp...     »
Zeitschriftentitel:
Nature
Jahr:
2016
Band / Volume:
531
Heft / Issue:
7593
Seitenangaben Beitrag:
253-7
Sprache:
eng
Volltext / DOI:
doi:10.1038/nature16969
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26934227
Print-ISSN:
0028-0836
TUM Einrichtung:
Institut für Virologie
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