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Title:

B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.

Document type:
Journal Article
Author(s):
Lehmann-Horn, Klaus; Wang, Sheng-Zhi; Sagan, Sharon A; Zamvil, Scott S; von Büdingen, H-Christian
Abstract:
Ectopic lymphoid tissues (ELT) can be found in multiple sclerosis (MS) and other organ-specific inflammatory conditions. Whether ELT in the meninges of central nervous system (CNS) autoimmune disease exhibit local germinal center (GC) activity remains unknown. In an experimental autoimmune encephalomyelitis model of CNS autoimmunity, we found activation-induced cytidine deaminase, a GC-defining enzyme, in meningeal ELT (mELT) densely populated by B and T cells. To determine GC activity in mELT,...     »
Journal title abbreviation:
JCI Insight
Year:
2016
Journal volume:
1
Journal issue:
20
Pages contribution:
e87234
Language:
eng
Fulltext / DOI:
doi:10.1172/jci.insight.87234
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27942581
Print-ISSN:
2379-3708
TUM Institution:
Neurologische Klinik und Poliklinik
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