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Titel:

CARD9 Promotes Sex-Biased Colon Tumors in the APCmin Mouse Model.

Dokumenttyp:
Journal Article
Autor(en):
Leo, Vonny I; Tan, Sze Huey; Bergmann, Hanna; Cheah, Peh Yean; Chew, Min Hoe; Lim, Kiat Hon; Ruland, Jürgen; Reilly, Patrick T
Abstract:
Caspase recuitment domain-containing protein 9 (CARD9) functions in different inflammation pathways to elicit responses to microbial signals and is known to affect intestinal inflammation. Examining the APC(min) mouse model of intestinal tumorigenesis and using stringently controlled, sex- and age-matched pairs of CARD9-competent and CARD9-deficient mice, we have found that CARD9 has a restricted but strong effect on tumorigenesis in the large intestine. We have found that CARD9 reduces viabilit...     »
Zeitschriftentitel:
Cancer Immunol Res
Jahr:
2015
Band / Volume:
3
Heft / Issue:
7
Seitenangaben Beitrag:
721-6
Sprache:
eng
Volltext / DOI:
doi:10.1158/2326-6066.CIR-14-0148
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25941350
Print-ISSN:
2326-6066
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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