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Titel:

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study.

Dokumenttyp:
Journal Article; Article
Autor(en):
Kübler, Hubert; Scheel, Birgit; Gnad-Vogt, Ulrike; Miller, Kurt; Schultze-Seemann, Wolfgang; Vom Dorp, Frank; Parmiani, Giorgio; Hampel, Christian; Wedel, Steffen; Trojan, Lutz; Jocham, Dieter; Maurer, Tobias; Rippin, Gerd; Fotin-Mleczek, Mariola; von der Mülbe, Florian; Probst, Jochen; Hoerr, Ingmar; Kallen, Karl-Josef; Lander, Thomas; Stenzl, Arnulf
Abstract:
CV9103 is a prostate-cancer vaccine containing self-adjuvanted mRNA (RNActive®) encoding the antigens PSA, PSCA, PSMA, and STEAP1. This phase I/IIa study evaluated safety and immunogenicity of CV9103 in patients with advanced castration-resistant prostate-cancer.44 Patients received up to 5 intra-dermal vaccinations. Three dose levels of total mRNA were tested in Phase I in cohorts of 3-6 patients to determine a recommended dose. In phase II, 32 additional patients were treated at the recommende...     »
Zeitschriftentitel:
J Immunother Cancer
Jahr:
2015
Band / Volume:
3
Seitenangaben Beitrag:
26
Sprache:
eng
Volltext / DOI:
doi:10.1186/s40425-015-0068-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26082837
TUM Einrichtung:
Urologische Klinik und Poliklinik
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