Benutzer: Gast  Login
Titel:

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
de Angelis, Martin Hrab?; Nicholson, George; Selloum, Mohammed; White, Jacqueline K; Morgan, Hugh; Ramirez-Solis, Ramiro; Sorg, Tania; Wells, Sara; Fuchs, Helmut; Fray, Martin; Adams, David J; Adams, Niels C; Adler, Thure; Aguilar-Pimentel, Antonio; Ali-Hadji, Dalila; Amann, Gregory; André, Philippe; Atkins, Sarah; Auburtin, Aurelie; Ayadi, Abdel; Becker, Julien; Becker, Lore; Bedu, Elodie; Bekeredjian, Raffi; Birling, Marie-Christine; Blake, Andrew; Bottomley, Joanna; Bowl, Michael R; Brault, V...     »
Abstract:
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproduci...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2015
Band / Volume:
47
Heft / Issue:
9
Seitenangaben Beitrag:
969-78
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.3360
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26214591
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
 BibTeX