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Title:

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network.

Document type:
Journal Article; Article
Author(s):
Lee, Seonjoo; Viqar, Fawad; Zimmerman, Molly E; Narkhede, Atul; Tosto, Giuseppe; Benzinger, Tammie L S; Marcus, Daniel S; Fagan, Anne M; Goate, Alison; Fox, Nick C; Cairns, Nigel J; Holtzman, David M; Buckles, Virginia; Ghetti, Bernardino; McDade, Eric; Martins, Ralph N; Saykin, Andrew J; Masters, Colin L; Ringman, John M; Ryan, Natalie S; Forster, Stefan; Laske, Christoph; Schofield, Peter R; Sperling, Reisa A; Salloway, Stephen; Correia, Stephen; Jack, Clifford; Weiner, Michael; Bateman, Randa...     »
Abstract:
White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression of Alzheimer's disease (AD). These observations are typically interpreted as evidence that vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features of AD. We examined the severity and distribu...     »
Journal title abbreviation:
Ann Neurol
Year:
2016
Journal volume:
79
Journal issue:
6
Pages contribution:
929-39
Language:
eng
Fulltext / DOI:
doi:10.1002/ana.24647
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27016429
Print-ISSN:
0364-5134
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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