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Title:

HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances.

Document type:
Journal Article; Article
Author(s):
Schulz, Dominik; Wirth, Markus; Piontek, Guido; Buchberger, Anna Maria Stefanie; Schlegel, Jürgen; Reiter, Rudolf; Multhoff, Gabriele; Pickhard, Anja
Abstract:
Despite remarkable successes with targeted therapies in the treatment of cancer, resistance can occur which limits the clinical outcome. In this study, we generated and characterized resistant cell clones derived from two different head and neck squamous cell carcinoma (HNSCC) cell lines (Cal27, UD-SCC-5) by long-term exposure to five targeted- and chemotherapeutics (afatinib, MK2206, BEZ235, olaparib and cisplatin). The resistant tumor cell clones showed an increased ERK1/2 expression and an al...     »
Journal title abbreviation:
Am J Cancer Res
Year:
2016
Journal volume:
6
Journal issue:
9
Pages contribution:
1963-1975
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27725902
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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