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Title:

Impact of NKT Cells and LFA-1 on Liver Regeneration under Subseptic Conditions.

Document type:
Journal Article; Article
Author(s):
Jörger, Ann-Kathrin; Liu, Lei; Fehlner, Karin; Weisser, Tanja; Cheng, Zhangjun; Lu, Miao; Höchst, Bastian; Bolzer, Andreas; Wang, Baocai; Hartmann, Daniel; Assfalg, Volker; Sunami, Yoshiaki; Schlitter, Anna Melissa; Friess, Helmut; Hüser, Norbert; Laschinger, Melanie
Abstract:
Activation of the immune system in terms of subseptic conditions during liver regeneration is of paramount clinical importance. However, little is known about molecular mechanisms and their mediators that control hepatocyte proliferation. We sought to determine the functional role of immune cells, especially NKT cells, in response to partial hepatectomy (PH), and to uncover the impact of the integrin lymphocyte function-associated antigen-1 (LFA-1) on liver regeneration in a subseptic setting.Wi...     »
Journal title abbreviation:
PLoS ONE
Year:
2016
Journal volume:
11
Journal issue:
12
Pages contribution:
e0168001
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0168001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27977747
Print-ISSN:
1932-6203
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Roman Herzog Comprehensive Cancer Center
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