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Title:

The Role of PD-L1 Expression and Intratumoral Lymphocytes in Response to Perioperative Chemotherapy for Urothelial Carcinoma.

Document type:
Journal Article
Author(s):
Erlmeier, F; Seitz, A K; Hatzichristodoulou, G; Stecher, L; Retz, M; Gschwend, J E; Weichert, W; Kübler, H R; Horn, T
Abstract:
Introduction: Immunological pathways are relevant for the effectiveness of conventional cytotoxic chemotherapy. Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma. Objective: To monitor PD-L1 expression on tumor cells and intratumoral infiltration with CD8 positive lymphocytes during perioperative chemotherapy for urothelial cancer and to evaluate their use as potential predictive markers for chemotherapy. Patients and Met...     »
Journal title abbreviation:
Bladder Cancer
Year:
2016
Journal volume:
2
Journal issue:
4
Pages contribution:
425-432
Language:
eng
Fulltext / DOI:
doi:10.3233/BLC-160067
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28035323
Print-ISSN:
2352-3727
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Urologische Klinik und Poliklinik
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