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Document type:
Journal Article 
Author(s):
Friedrich, Teresa; Söhn, Michaela; Gutting, Tobias; Janssen, Klaus-Peter; Behrens, Hans-Michael; Röcken, Christoph; Ebert, Matthias P A; Burgermeister, Elke 
Title:
Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer. 
Abstract:
Full-length (FL) docking protein-1 (DOK1) is an adapter protein which inhibits growth factor and immune response pathways in normal tissues, but is frequently lost in human cancers. Small DOK1 variants remain in cells of solid tumors and leukemias, albeit, their functions are elusive. To assess the so far unknown role of DOK1 in colorectal cancer (CRC), we generated DOK1 mutants which mimic the domain structure and subcellular distribution of DOK1 protein variants in leukemia patients. We found...    »
 
Journal title abbreviation:
EBioMedicine 
Year:
2016 
Journal volume:
Pages contribution:
159-72 
Language:
eng 
TUM Institution:
Chirurgische Klinik und Poliklinik