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- Title:
Extracellular MRP8/14 is a regulator of ?2 integrin-dependent neutrophil slow rolling and adhesion.
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Pruenster, Monika; Kurz, Angela R M; Chung, Kyoung-Jin; Cao-Ehlker, Xiao; Bieber, Stephanie; Nussbaum, Claudia F; Bierschenk, Susanne; Eggersmann, Tanja K; Rohwedder, Ina; Heinig, Kristina; Immler, Roland; Moser, Markus; Koedel, Uwe; Gran, Sandra; McEver, Rodger P; Vestweber, Dietmar; Verschoor, Admar; Leanderson, Tomas; Chavakis, Triantafyllos; Roth, Johannes; Vogl, Thomas; Sperandio, Markus
- Abstract:
- Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released MRP8/14 in turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway of rapid ?... »
- Journal title abbreviation:
- Nat Commun
- Year:
- 2015
- Journal volume:
- 6
- Pages contribution:
- 6915
- Language:
- eng
- Fulltext / DOI:
- doi:10.1038/ncomms7915
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/25892652
- Print-ISSN:
- 2041-1723
- TUM Institution:
- Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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