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Titel:

Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.

Dokumenttyp:
Journal Article
Autor(en):
Keller, Birgit; Mühlenkamp, Melanie; Deuschle, Eva; Siegfried, Alexandra; Mössner, Sara; Schade, Jessica; Griesinger, Tanja; Katava, Nenad; Braunsdorf, Christina; Fehrenbacher, Birgit; Jiménez-Soto, Luisa F; Schaller, Martin; Haas, Rainer; Genth, Harald; Retta, Saverio F; Meyer, Hannelore; Böttcher, Ralph T; Zent, Roy; Schütz, Monika; Autenrieth, Ingo B; Bohn, Erwin
Abstract:
The current paradigm suggests that Yersinia enterocolitica (Ye) adheres to host cells via the outer membrane proteins Yersinia adhesin A (YadA) or invasin (Inv) to facilitate injection of Yops by the type III secretion system. In this process Inv binds directly to ?1 integrins of host cells while YadA may bind indirectly via extracellular matrix proteins to ?1 integrins. Here we challenged this paradigm and investigated the requirements for Yop injection. We demonstrate that Inv- but not YadA-me...     »
Zeitschriftentitel:
Cell Microbiol
Jahr:
2015
Band / Volume:
17
Heft / Issue:
8
Seitenangaben Beitrag:
1179-204
Sprache:
eng
Volltext / DOI:
doi:10.1111/cmi.12429
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25678064
Print-ISSN:
1462-5814
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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