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Title:

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.

Document type:
Journal Article
Author(s):
Seidensaal, Katharina; Nollert, Andre; Feige, Agnes Hiou; Muller, Marie; Fleming, Thomas; Gunkel, Nikolas; Zaoui, Karim; Grabe, Niels; Weichert, Wilko; Weber, Klaus-Josef; Plinkert, Peter; Simon, Christian; Hess, Jochen
Abstract:
An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OPSCC patients, however the causal link between reduced ALDH1A2 function and treatment failure has not been addressed so far.Serial sections from tissue microarrays of patients with primary OPSCC (n = 1...     »
Journal title abbreviation:
Mol Cancer
Year:
2015
Journal volume:
14
Journal issue:
1
Pages contribution:
204
Language:
eng
Fulltext / DOI:
doi:10.1186/s12943-015-0476-0
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26634247
Print-ISSN:
1476-4598
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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