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Titel:

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Seidensaal, Katharina; Nollert, Andre; Feige, Agnes Hiou; Muller, Marie; Fleming, Thomas; Gunkel, Nikolas; Zaoui, Karim; Grabe, Niels; Weichert, Wilko; Weber, Klaus-Josef; Plinkert, Peter; Simon, Christian; Hess, Jochen
Abstract:
An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OPSCC patients, however the causal link between reduced ALDH1A2 function and treatment failure has not been addressed so far.Serial sections from tissue microarrays of patients with primary OPSCC (n = 1...     »
Zeitschriftentitel:
Mol Cancer
Jahr:
2015
Band / Volume:
14
Heft / Issue:
1
Seitenangaben Beitrag:
204
Sprache:
eng
Volltext / DOI:
doi:10.1186/s12943-015-0476-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26634247
Print-ISSN:
1476-4598
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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