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Titel:

An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Orabi, Ahmed; Bieringer, Maria; Geerlof, Arie; Bruss, Volker
Abstract:
The hepatitis B virus (HBV) particle is an icosahedral nucleocapsid surrounded by a lipid envelope containing viral surface proteins. A small domain (matrix domain [MD]) in the large surface protein L and a narrow region (matrix binding domain [MBD]) including isoleucine 126 on the capsid surface have been mapped, in which point mutations such as core I126A specifically blocked nucleocapsid envelopment. It is possible that the two domains interact with each other during virion morphogenesis. By...     »
Zeitschriftentitel:
J Virol
Jahr:
2015
Band / Volume:
89
Heft / Issue:
18
Seitenangaben Beitrag:
9281-7
Sprache:
eng
Volltext / DOI:
doi:10.1128/JVI.00466-15
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26136564
Print-ISSN:
0022-538X
TUM Einrichtung:
Institut für Virologie
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