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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Goldmann, Tobias; Zeller, Nicolas; Raasch, Jenni; Kierdorf, Katrin; Frenzel, Kathrin; Ketscher, Lars; Basters, Anja; Staszewski, Ori; Brendecke, Stefanie M; Spiess, Alena; Tay, Tuan Leng; Kreutz, Clemens; Timmer, Jens; Mancini, Grazia M S; Blank, Thomas; Fritz, Günter; Biber, Knut; Lang, Roland; Malo, Danielle; Merkler, Doron; Heikenwälder, Mathias; Knobeloch, Klaus-Peter; Prinz, Marco
Titel:
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
Abstract:
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, called "microgliopathies". However, how the intracellular stimulation machinery in microglia is controlled is poorly understood. Here, we identified the ubiquitin-specific protease (Usp) 18 in white matter microglia that essentially contributes to microglial quiescen...     »
Zeitschriftentitel:
EMBO J
Jahr:
2015
Band / Volume:
34
Heft / Issue:
12
Seitenangaben Beitrag:
1612-29
Sprache:
eng
Volltext / DOI:
doi:10.15252/embj.201490791
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25896511
Print-ISSN:
0261-4189
TUM Einrichtung:
Institut für Virologie
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