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Title:

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Mattusch, Corinna; Kratzer, Stephan; Buerge, Martina; Kreuzer, Matthias; Engel, Tatiana; Kopp, Claudia; Biel, Martin; Hammelmann, Verena; Ying, Shui-Wang; Goldstein, Peter A; Kochs, Eberhard; Haseneder, Rainer; Rammes, Gerhard
Abstract:
The thalamus is thought to be crucially involved in the anesthetic state. Here, we investigated the effect of the inhaled anesthetic xenon on stimulus-evoked thalamocortical network activity and on excitability of thalamocortical neurons. Because hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are key regulators of neuronal excitability in the thalamus, the effect of xenon on HCN channels was examined.The effects of xenon on thalamocortical network activity were invest...     »
Journal title abbreviation:
Anesthesiology
Year:
2015
Journal volume:
122
Journal issue:
5
Pages contribution:
1047-59
Language:
eng
Fulltext / DOI:
doi:10.1097/ALN.0000000000000635
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25782754
Print-ISSN:
0003-3022
TUM Institution:
Klinik für Anästhesiologie (DHM)
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