User: Guest  Login
Title:

T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schwartz, Christian; Oeser, Katharina; Prazeres da Costa, Clarissa; Layland, Laura E; Voehringer, David
Abstract:
Schistosomiasis is a severe and chronic disease caused by the parasitic trematode Schistosoma mansoni after deposition of eggs in the liver and intestines. The immune response to S. mansoni eggs is characterized by increased Th2 cells, eosinophilia, and high serum IgE levels. Granulomas are formed around the eggs to protect the organs against tissue damage caused by toxic products that are secreted from the eggs. Egg-derived components have further been shown to activate the IgE-mediated release...     »
Journal title abbreviation:
J Immunol
Year:
2014
Journal volume:
193
Journal issue:
7
Pages contribution:
3590-9
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1401155
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25172500
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX