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Titel:

T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Schwartz, Christian; Oeser, Katharina; Prazeres da Costa, Clarissa; Layland, Laura E; Voehringer, David
Abstract:
Schistosomiasis is a severe and chronic disease caused by the parasitic trematode Schistosoma mansoni after deposition of eggs in the liver and intestines. The immune response to S. mansoni eggs is characterized by increased Th2 cells, eosinophilia, and high serum IgE levels. Granulomas are formed around the eggs to protect the organs against tissue damage caused by toxic products that are secreted from the eggs. Egg-derived components have further been shown to activate the IgE-mediated release...     »
Zeitschriftentitel:
J Immunol
Jahr:
2014
Band / Volume:
193
Heft / Issue:
7
Seitenangaben Beitrag:
3590-9
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1401155
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25172500
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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