Prognostic value of bleeding after percutaneous coronary intervention in patients with diabetes.

Ndrepepa, Gjin; Schulz, Stefanie; Neumann, Franz-Josef; Laugwitz, Karl-Ludwig; Richardt, Gert; Byrne, Robert A; Pöhler, Anja; Kastrati, Adnan; Pache, Jürgen

doi:10.4244/EIJV10I1A14

2014

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Title:: Prognostic value of bleeding after percutaneous coronary intervention in patients with diabetes.
Document type:: Journal Article; Article
Author(s):: Ndrepepa, Gjin; Schulz, Stefanie; Neumann, Franz-Josef; Laugwitz, Karl-Ludwig; Richardt, Gert; Byrne, Robert A; Pöhler, Anja; Kastrati, Adnan; Pache, Jürgen
Abstract:: The aim of this study was to assess the impact of bleeding after percutaneous coronary intervention (PCI) on the outcome of patients with type 2 diabetes.This study included 4,329 diabetic patients who underwent PCI. Bleeding was assessed using the Bleeding Academic Research Consortium criteria. The primary outcome was one-year mortality. Bleeding events occurred in 474 patients (10.9%). Access-site and non-access-site bleeds occurred in 274 patients (58%) and 200 patients (42%), respectively. Within the first year after PCI there were 198 deaths: 45 deaths (9.6%) among patients with bleeding and 153 deaths (4.0%) among patients without bleeding (adjusted hazard ratio=2.04 [95% confidence interval 1.38-3.00], p<0.001). There were 25 deaths (12.7%) among patients with non-access-site bleeding and 20 deaths (7.4%) among patients with access-site bleeding (odds ratio [OR]=3.45 [2.20-5.41], p<0.001 for non-access-site bleeding vs. no bleeding and OR=1.90 [1.17-3.01], p=0.008 for access-site bleeding vs. no bleeding). Bleeding improved the discriminatory power of the multivariable model for mortality prediction (p=0.002).In patients with diabetes undergoing PCI, occurrence of bleeding within the first 30 days after PCI was associated with a significant increase in the risk of one-year mortality.
Journal title abbreviation:: EuroIntervention
Year:: 2014
Journal volume:: 10
Journal issue:: 1
Pages contribution:: 83-9
Language:: eng
Fulltext / DOI:: doi:10.4244/EIJV10I1A14
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/24694461
Print-ISSN:: 1774-024X
TUM Institution:: I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2014

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2014