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Title:

Angiotensin II dose-dependently stimulates human renal proximal tubule transport by the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Shirai, Ayumi; Yamazaki, Osamu; Horita, Shoko; Nakamura, Motonobu; Satoh, Nobuhiko; Yamada, Hideomi; Suzuki, Masashi; Kudo, Akihiko; Kawakami, Hayato; Hofmann, Franz; Nishiyama, Akira; Kume, Haruki; Enomoto, Yutaka; Homma, Yukio; Seki, George
Abstract:
Stimulation of renal proximal tubule (PT) transport by angiotensin II (Ang II) is critical for regulation of BP. Notably, in rats, mice, and rabbits, the regulation of PT sodium transport by Ang II is biphasic: transport is stimulated by picomolar to nanomolar concentrations of Ang II but inhibited by nanomolar to micromolar concentrations of Ang II. However, little is known about the effects of Ang II on human PT transport. By functional analysis with isolated PTs obtained from nephrectomy surg...     »
Journal title abbreviation:
J Am Soc Nephrol
Year:
2014
Journal volume:
25
Journal issue:
7
Pages contribution:
1523-32
Language:
eng
Fulltext / DOI:
doi:10.1681/ASN.2013060596
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24511122
Print-ISSN:
1046-6673
TUM Institution:
Institut für Pharmakologie und Toxikologie
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