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Title:

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bang, Claudia; Batkai, Sandor; Dangwal, Seema; Gupta, Shashi Kumar; Foinquinos, Ariana; Holzmann, Angelika; Just, Annette; Remke, Janet; Zimmer, Karina; Zeug, Andre; Ponimaskin, Evgeni; Schmiedl, Andreas; Yin, Xiaoke; Mayr, Manuel; Halder, Rashi; Fischer, Andre; Engelhardt, Stefan; Wei, Yuanyuan; Schober, Andreas; Fiedler, Jan; Thum, Thomas
Abstract:
In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure. Alterations in microRNA (miRNA) levels are associated with dysfunctional gene expression profiles associated with many cardiovascular disease conditions; however, miRNAs have emerged recently as paracrine signaling mediators. Thus, we investigated a potential paracrine miRNA crosstalk between cardiac...     »
Journal title abbreviation:
J Clin Invest
Year:
2014
Journal volume:
124
Journal issue:
5
Pages contribution:
2136-46
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI70577
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24743145
Print-ISSN:
0021-9738
TUM Institution:
Institut für Pharmakologie und Toxikologie
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