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Titel:

Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Hartmann, Thomas; Xu, Xinsong; Kronast, Mira; Muehlich, Susanne; Meyer, Kathleen; Zimmermann, Wolfgang; Hurwitz, Jerard; Pan, Zhen-Qiang; Engelhardt, Stefan; Sarikas, Antonio
Abstract:
Simian virus 40 (SV40) large tumor antigen (LT) triggers oncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of the retinoblastoma family. In addition, SV40 transformation requires binding of LT to Cullin 7 (CUL7), a core component of Cullin-RING E3 ubiquitin ligase 7 (CRL7). However, the pathomechanistic effects of LT-CUL7 interaction are mostly unknown. Here we report both in vitro and in vivo experimental evidence that SV40 LT suppresses the ubiq...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2014
Band / Volume:
111
Heft / Issue:
9
Seitenangaben Beitrag:
3371-6
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1401556111
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24550499
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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