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Titel:

Function of cGMP-dependent protein kinase II in volume load-induced diuresis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schramm, Andrea; Schinner, Elisabeth; Huettner, Johannes P; Kees, Frieder; Tauber, Philipp; Hofmann, Franz; Schlossmann, Jens
Abstract:
Atrial natriuretic peptide (ANP)/cGMPs cause diuresis and natriuresis. Their downstream effectors beyond cGMP remain unclear. To elucidate a probable function of cGMP-dependent protein kinase II (cGKII), we investigated renal parameters in different conditions (basal, salt diets, starving, water load) using a genetically modified mouse model (cGKII-KO), but did not detect any striking differences between WT and cGKII-KO. Thus, cGKII is proposed to play only a marginal role in the adjustment of r...     »
Zeitschriftentitel:
Pflugers Arch
Jahr:
2014
Band / Volume:
466
Heft / Issue:
10
Seitenangaben Beitrag:
2009-18
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00424-014-1445-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24442122
Print-ISSN:
0031-6768
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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