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Titel:

Expression of cGMP-dependent protein kinase type I in mature white adipocytes.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Leiss, Veronika; Illison, Julia; Domes, Katrin; Hofmann, Franz; Lukowski, Robert
Abstract:
The presence of cGMP-dependent protein kinase I (cGKI) in murine adipocytes has been questioned, although cGKI was implicated in the thermogenic program of fat cells (FCs) and to exert anti-hypertrophic/-inflammatory effects in white adipose tissue. Herein, cGKI was detected in adipocytes from control mice, whereas FCs from global cGKI knockouts (cGKI(-/-)) and cGKI? rescue (?RM) mice remained cGKI-negative. cGKI mutants exhibit decreased adipocyte size, plasma leptin levels and reduced body-wei...     »
Zeitschriftentitel:
Biochem Biophys Res Commun
Jahr:
2014
Band / Volume:
452
Heft / Issue:
1
Seitenangaben Beitrag:
151-6
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bbrc.2014.08.071
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25152402
Print-ISSN:
0006-291X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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