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Titel:

Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Wang, R; Kwon, I-K; Singh, N; Islam, B; Liu, K; Sridhar, S; Hofmann, F; Browning, D D
Abstract:
Analysis of knockout animals indicates that 3',5'cyclic guanosine monophosphate (cGMP) has an important role in gut homeostasis but the signaling mechanism is not known. The goals of this study were to test whether increasing cGMP could affect colon homeostasis and determine the mechanism. We increased cGMP in the gut of Prkg2(+/+) and Prkg2(-/-) mice by treating with the PDE5 inhibitor Vardenafil (IP). Proliferation, differentiation and apoptosis in the colon mucosa were then quantitated. Varde...     »
Zeitschriftentitel:
Cell Death Differ
Jahr:
2014
Band / Volume:
21
Heft / Issue:
3
Seitenangaben Beitrag:
427-37
Sprache:
eng
Volltext / DOI:
doi:10.1038/cdd.2013.163
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24270408
Print-ISSN:
1350-9047
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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