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Titel:

FHL2 expression and variants in hypertrophic cardiomyopathy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Friedrich, Felix W; Reischmann, Silke; Schwalm, Aileen; Unger, Andreas; Ramanujam, Deepak; Münch, Julia; Müller, Oliver J; Hengstenberg, Christian; Galve, Enrique; Charron, Philippe; Linke, Wolfgang A; Engelhardt, Stefan; Patten, Monica; Richard, Pascale; van der Velden, Jolanda; Eschenhagen, Thomas; Isnard, Richard; Carrier, Lucie
Abstract:
Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis and is mainly caused by mutations in genes coding for sarcomeric proteins. FHL2 mRNA level, FHL2 protein level and I-band-binding density were l...     »
Zeitschriftentitel:
Basic Res Cardiol
Jahr:
2014
Band / Volume:
109
Heft / Issue:
6
Seitenangaben Beitrag:
451
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00395-014-0451-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25358972
Print-ISSN:
0300-8428
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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