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Titel:

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Werfel, Stanislas; Jungmann, Andreas; Lehmann, Lorenz; Ksienzyk, Jan; Bekeredjian, Raffi; Kaya, Ziya; Leuchs, Barbara; Nordheim, Alfred; Backs, Johannes; Engelhardt, Stefan; Katus, Hugo A; Müller, Oliver J
Abstract:
Inducible gene targeting in mice using the Cre/LoxP system has become a valuable tool to analyse the roles of specific genes in the adult heart. However, the commonly used Myh6-MerCreMer system requires time-consuming breeding schedules and is potentially associated with cardiac side effects, which may result in transient cardiac dysfunction. The aim of our study was to establish a rapid and simple system for cardiac gene inactivation in conditional knockout mice by gene transfer of a Cre recomb...     »
Zeitschriftentitel:
Cardiovasc Res
Jahr:
2014
Band / Volume:
104
Heft / Issue:
1
Seitenangaben Beitrag:
15-23
Sprache:
eng
Volltext / DOI:
doi:10.1093/cvr/cvu174
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25082846
Print-ISSN:
0008-6363
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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