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Titel:

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Bang, Claudia; Batkai, Sandor; Dangwal, Seema; Gupta, Shashi Kumar; Foinquinos, Ariana; Holzmann, Angelika; Just, Annette; Remke, Janet; Zimmer, Karina; Zeug, Andre; Ponimaskin, Evgeni; Schmiedl, Andreas; Yin, Xiaoke; Mayr, Manuel; Halder, Rashi; Fischer, Andre; Engelhardt, Stefan; Wei, Yuanyuan; Schober, Andreas; Fiedler, Jan; Thum, Thomas
Abstract:
In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure. Alterations in microRNA (miRNA) levels are associated with dysfunctional gene expression profiles associated with many cardiovascular disease conditions; however, miRNAs have emerged recently as paracrine signaling mediators. Thus, we investigated a potential paracrine miRNA crosstalk between cardiac...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2014
Band / Volume:
124
Heft / Issue:
5
Seitenangaben Beitrag:
2136-46
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI70577
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24743145
Print-ISSN:
0021-9738
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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