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Titel:

cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Wincott, Charlotte M; Abera, Sinedu; Vunck, Sarah A; Tirko, Natasha; Choi, Yoon; Titcombe, Roseann F; Antoine, Shannon O; Tukey, David S; Devito, Loren M; Hofmann, Franz; Hoeffer, Charles A; Ziff, Edward B
Abstract:
Neuronal activity regulates AMPA receptor trafficking, a process that mediates changes in synaptic strength, a key component of learning and memory. This form of plasticity may be induced by stimulation of the NMDA receptor which, among its activities, increases cyclic guanosine monophosphate (cGMP) through the nitric oxide synthase pathway. cGMP-dependent protein kinase type II (cGKII) is ultimately activated via this mechanism and AMPA receptor subunit GluA1 is phosphorylated at serine 845. Th...     »
Zeitschriftentitel:
Neurobiol Learn Mem
Jahr:
2014
Band / Volume:
114
Seitenangaben Beitrag:
32-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.nlm.2014.04.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24752151
Print-ISSN:
1074-7427
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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