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Title:

Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy

Document type:
Zeitschriftenaufsatz
Author(s):
Liu, Nian; O'Connor, Patrick; Gujrati, Vipul; Shelar, Divyesh; Ma, Xiaopeng; Anzenhofer, Pia; Klemm, Uwe; Su, Xinhui; Huang, Yuanhui; Kleigrewe, Karin; Feuchtinger, Annette; Walch, Axel; Sattler, Michael; Plettenburg, Oliver; Ntziachristos, Vasilis
Abstract:
Cyanine derivatives are organic dyes widely used for optical imaging. However, their potential in longitudinal optoacoustic imaging and photothermal therapy remains limited due to challenges such as poor chemical stability, poor photostability, and low photothermal conversion. In this study, we present a new structural modification for cyanine dyes by introducing a strongly electron-withdrawing group (barbiturate), resulting in a new series of barbiturate-cyanine dyes (BC810, BC885, and BC1010)...     »
Keywords:
BayBioMS; Barbiturate functionalization; Cyanine; NIR-II excitation; Nanoformulation; Optoacoustic; Photothermal therapy
Journal title:
Journal of Controlled Release
Year:
2024
Journal volume:
372
Pages contribution:
522-530
Fulltext / DOI:
doi:10.1016/j.jconrel.2024.06.037
Publisher:
Elsevier BV
E-ISSN:
0168-3659
Date of publication:
01.08.2024
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