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Title:

Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity

Document type:
Zeitschriftenaufsatz
Author(s):
Brunner, Sarah; Höring, Marcus; Liebisch, Gerhard; Schweizer, Sabine; Scheiber, Josef; Giansanti, Piero; Hidrobo, Maria; Hermeling, Sven; Oeckl, Josef; Prudente de Mello, Natalia; Perocchi, Fabiana; Seeliger, Claudine; Strohmeyer, Akim; Klingenspor, Martin; Plagge, Johannes; Küster, Bernhard; Burkhardt, Ralph; Janssen, Klaus-Peter; Ecker, Josef
Abstract:
Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold higher in brown than white adipose tissue mitochondria. Their purity was verified by comparison of proteomes with ER and mitochondria-associated membranes. A lipid signature containing P...     »
Keywords:
BayBioMS;
Journal title:
Life Science Alliance
Year:
2024
Journal volume:
7
Journal issue:
8
Pages contribution:
e202402828
Fulltext / DOI:
doi:10.26508/lsa.202402828
Publisher:
Life Science Alliance, LLC
E-ISSN:
2575-1077
Date of publication:
06.06.2024
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