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Title:

Multi-omics characterization of the monkeypox virus infection

Document type:
Zeitschriftenaufsatz
Author(s):
Huang, Yiqi; Bergant, Valter; Grass, Vincent; Emslander, Quirin; Hamad, M. Sabri; Hubel, Philipp; Mergner, Julia; Piras, Antonio; Krey, Karsten; Henrici, Alexander; Öllinger, Rupert; Tesfamariam, Yonas M.; Dalla Rosa, Ilaria; Bunse, Till; Sutter, Gerd; Ebert, Gregor; Schmidt, Florian I.; Way, Michael; Rad, Roland; Bowie, Andrew G.; Protzer, Ulrike; Pichlmair, Andreas
Abstract:
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation despite its high sequence similarity to VACV. Here, we perform an in-depth multi-omics analysis of the transcriptome, proteome, and phosphoproteome signatures of MPXV-infected primary human fibroblasts to gain insights into the virus-host interplay. In addition...     »
Keywords:
BayBioMS@MRI; Pox virus, Cell signalling, Proteomics, Phosphorylation
Journal title:
Nature Communications
Year:
2024
Journal volume:
15
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-024-51074-6
Publisher:
Springer Science and Business Media LLC
E-ISSN:
2041-1723
Date of publication:
08.08.2024
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