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Titel:

Changes in the Proteome of the Circle of Willis during Aging Reveal Signatures of Vascular Disease

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Subramanian, Vikram; Juhr, Denise; Johnson, Lydia S.; Yem, Justin B.; Giansanti, Piero; Grumbach, Isabella M.
Abstract:
Approximately 70% of all strokes occur in patients over 65 years old, and stroke increases the risk of developing dementia. The circle of Willis (CoW), the ring of arteries at the base of the brain, links the intracerebral arteries to one another to maintain adequate cerebral perfusion. The CoW proteome is affected in cerebrovascular and neurodegenerative diseases, but changes related to aging have not been described. Here, we report on a quantitative proteomics analysis comparing the CoW from f...     »
Stichworte:
BayBioMS@MRI;
Zeitschriftentitel:
Oxidative Medicine and Cellular Longevity
Jahr:
2024
Band / Volume:
2024
Heft / Issue:
1
Volltext / DOI:
doi:10.1155/2024/4887877
Verlag / Institution:
Wiley
E-ISSN:
1942-09001942-0994
Publikationsdatum:
01.01.2024
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