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Titel:

Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Liu, Nian; O'Connor, Patrick; Gujrati, Vipul; Shelar, Divyesh; Ma, Xiaopeng; Anzenhofer, Pia; Klemm, Uwe; Su, Xinhui; Huang, Yuanhui; Kleigrewe, Karin; Feuchtinger, Annette; Walch, Axel; Sattler, Michael; Plettenburg, Oliver; Ntziachristos, Vasilis
Abstract:
Cyanine derivatives are organic dyes widely used for optical imaging. However, their potential in longitudinal optoacoustic imaging and photothermal therapy remains limited due to challenges such as poor chemical stability, poor photostability, and low photothermal conversion. In this study, we present a new structural modification for cyanine dyes by introducing a strongly electron-withdrawing group (barbiturate), resulting in a new series of barbiturate-cyanine dyes (BC810, BC885, and BC1010)...     »
Stichworte:
BayBioMS; Barbiturate functionalization; Cyanine; NIR-II excitation; Nanoformulation; Optoacoustic; Photothermal therapy
Zeitschriftentitel:
Journal of Controlled Release
Jahr:
2024
Band / Volume:
372
Seitenangaben Beitrag:
522-530
Volltext / DOI:
doi:10.1016/j.jconrel.2024.06.037
Verlag / Institution:
Elsevier BV
E-ISSN:
0168-3659
Publikationsdatum:
01.08.2024
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