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Title:

Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zhou, Dingxi; Borsa, Mariana; Puleston, Daniel J; Zellner, Susanne; Capera, Jesusa; Sanderson, Sharon; Schifferer, Martina; Hester, Svenja S; Ge, Xin; Fischer, Roman; Jostins, Luke; Behrends, Christian; Alsaleh, Ghada; Simon, Anna Katharina
Abstract:
CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell proliferation relies on autophagy, but identification of the autophagosomal cargo involved is missing. Here we create a transgenic mouse model, to enable direct mapping of the proteinaceous content of autophagosomes in primary cells by LC3 proximity labelling. Interleukin-7 receptor-α, a cytokine receptor mostly found in naïve and memory T cells, is reproducib...     »
Journal title abbreviation:
Nat Commun
Year:
2022
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-022-32718-x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36055998
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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