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Title:

Oligodendrocytes as A New Therapeutic Target in Schizophrenia: From Histopathological Findings to Neuron-Oligodendrocyte Interaction.

Document type:
Review; Journal Article; Review
Author(s):
Raabe, Florian J; Slapakova, Lenka; Rossner, Moritz J; Cantuti-Castelvetri, Ludovico; Simons, Mikael; Falkai, Peter G; Schmitt, Andrea
Abstract:
Imaging and postmortem studies have revealed disturbed oligodendroglia-related processes in patients with schizophrenia and provided much evidence for disturbed myelination, irregular gene expression, and altered numbers of oligodendrocytes in the brains of schizophrenia patients. Oligodendrocyte deficits in schizophrenia might be a result of failed maturation and disturbed regeneration and may underlie the cognitive deficits of the disease, which are strongly associated with impaired long-term...     »
Journal title abbreviation:
Cells
Year:
2019
Journal volume:
8
Journal issue:
12
Fulltext / DOI:
doi:10.3390/cells8121496
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31771166
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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