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Document type:
Journal Article
Author(s):
Arends, Martina; Weber, Melanie; Papan, Cyrus; Damm, Markus; Surma, Michal A; Spiegel, Christopher; Djannatian, Minou; Li, Shengrong; Connell, Lisa; Johannes, Ludger; Schifferer, Martina; Klose, Christian; Simons, Mikael
Title:
Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry.
Abstract:
Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known. Here, we present a direct infusion (shotgun) lipidomics method to analyze gangliosides in small amounts of tissue reproducibly and with high sensitivity. We resolve the mouse ganglioside lipidome during development and adulthood and determine the ganglioside content of mice lacking the St3gal5 and B4galnt1 genes that synthesi...     »
Journal title abbreviation:
iScience
Year:
2022
Journal volume:
25
Journal issue:
11
Fulltext / DOI:
doi:10.1016/j.isci.2022.105323
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36310581
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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